The prolactine hypothesis for peripartum cardiomyopathy: has it found its feet for good?
نویسندگان
چکیده
منابع مشابه
Remarks on the Prolactin Hypothesis of Peripartum Cardiomyopathy
A seminal study in 2007 introduced the hypothesis that an antiangiogenic prolactin fragment with a molecular mass of 16 kDa is a key pathological mediator of peripartum cardiomyopathy (PPCM) (1). The study reported that this fragment is enzymatically generated by the cleavage of full-length prolactin with the lysosomal aspartyl protease cathepsin D. Upon excessive generation, possibly due to hi...
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متن کاملPeripartum Cardiomyopathy
Peripartum cardiomyopathy (PPCM) is a rare but potentially lethal complication of pregnancy occurring in approximately 1in 3000 live births in the United States although some series report a much higher incidence. African-American women are particularly at risk. Diagnosis requires symptoms of heart failure in the last month of pregnancy or within five months of delivery in the absence of recogn...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2020
ISSN: 0195-668X,1522-9645
DOI: 10.1093/ehjci/ehaa946.2069